Insights & Research
Conference presentations, abstracts, and methodological contributions from our team.
Getting Closer to the Target: Practical Strategies to Hit the Mark in Trial Emulation
Le HV, Thomas Debray T, Aggarwal S, Opper N.
Comparing established and novel index date selection methods: a simulation study in two clinical contexts
Opper N, Aggarwal S, David Goldfarb D, Le HV.
Comparing line of therapy selection methods in advanced non-small cell lung cancer (aNSCLC): a simulation study
Aggarwal S, Opper N, Le HV.
Real-World Treatment Patterns and Clinical Outcomes in Patients With Extensive-Stage Small Cell Lung Cancer Treated With First-Line Platinum-Based Chemotherapy and ≥ 2 Subsequent Lines of Therapy in the United States
Sankar K et al.
DOI: 10.1007/s12325-025-03408-zPerformances of the Deep Learning Approach to Nonparametric Propensity Score Estimation with Optimized Covariate Balance in Small Samples
Le HV et al.
Performance of Machine Learning Predictions of Overall Survival After Multiple Imputations for Features Based on Absolute Non-Missing Degrees
Le HV et al.
Real-World Treatment Patterns and Outcomes in Patients With Extensive-Stage Small Cell Lung Cancer (ES-SCLC) Treated With First-Line Platinum-Based Chemotherapy (PBC) and ≥2 Subsequent Lines of Therapy in the United States
Sankar K et al.
Performance of ChatGPT-3.5, ChatGPT-4, Microsoft Copilot, and Google Bard To Identify Correct Information for Lung Cancer
Truong CT, Le HV.
Improvements of Machine Learning Predictions of Overall Survival After Multiple Imputations for Features Regardless of Their Missing Degrees
Le HV et al.
Improved Prediction of Overall Survival Using Machine Learning Survival Models Incorporating Time-Dependent Features
Le HV et al.
Effect of designations of index date in externally controlled trials: an empirical example
Le HV, Marc De Benedetti, Lihua Yue et al.
DOI: 10.1515/em-2023-0041Real-World Treatment Patterns and Clinical Outcomes Among Patients with Metastatic or Unresectable EGFR-Mutated Non-Small Cell Lung Cancer Previously Treated with Osimertinib and Platinum-Based Chemotherapy
Patel J, Meng J, Le HV, et al.
DOI: 10.1007/s12325-024-02936-4Use of a real-world synthetic control arm for direct comparison of lisocabtagene maraleucel and conventional therapy in relapsed/refractory large B-cell lymphoma
Le HV, Naarden KVB, Grzegorz S. Nowakowski et al.
DOI: 10.1080/10428194.2022.2160200Clinical Outcomes of Real-World Treatment for Metastatic EGFRm NSCLC after Osimertinib and Platinum-Based Chemotherapy
Jyoti Patel, Meng J, Le HV et al.
Creating a Real-World Data, United States Healthcare Claims-Based Adaptation of Kurtzke Functional Systems Scores for Assessing Multiple Sclerosis Severity and Progression
Le HV, Truong CT, Aaron W. Kamauu et al.
KarMMa-RW: comparison of idecabtagene vicleucel with real-world outcomes in relapsed and refractory multiple myeloma
Sundar Jagannath, Yi Lin, Hartmut Goldschmidt et al.
DOI: 10.1038/s41408-021-00507-2Creating a Real-World Data, United States Healthcare Claims-Based Adaptation of Kurtzke Functional Systems Scores for Assessing Multiple Sclerosis Severity and Progression
Truong CT, Le HV, Aaron Kamauu et al.
Machine Learning applied to SEER Data for Prediction of Breast Cancer Specific Survival
Phuong HL, Marc D Benedetti, Le HV et al.
Lessons Learned in Predicting Gastric Cancer Survival Using Machine Learning
Marc D Benedetti, Phuong HL et al.
Hospital Admission Patterns in Adult Patients with Community-Acquired Pneumonia Who Received Ceftriaxone and a Macrolide by Disease Severity across United States Hospitals
Thomas P Lodise, Le HV, Kenneth LaPensee.
DOI: 10.3390/antibiotics9090577Incidence and trends of skin cancer in the United States, 1999-2016
Le HV et al.
Prevalence of eosinophilia in the United States
Le HV et al.
Eosinophilia in atopic and non-atopic individuals in the United States
Chi L, Le HV et al.
KARMMA-RW: a study of real-world treatment patterns in heavily pretreated patients with relapsed and refractory multiple myeloma (RRMM) and comparison of outcomes to KARMMA
Hartmut Goldschmidt, Le HV et al.
Predicting the risk of medication discontinuation using machine learning
Le HV, Truong CT.
Using machine learning algorithms to improve the prediction accuracy of medication initiations
Le HV, Truong CT.
Incidence and Trends of Melanoma Skin Cancer in The United States, 1999-2016
Phuong L, Chi L, Truong TC et al.
Incidence Estimates and Trends of Non-melanoma Skin Cancer in The United States, 1999-2016
Chi L, Phuong L, Truong CT et al.
Risk of Death Associated with the Use of Antipsychotic Drugs Among Parkinson’s Disease Psychosis
Le HV et al.
Lessons Learned in Application of Machine Learning in Industry
Le HV, Truong CT.
Identifying relapsing-remitting multiple sclerosis (RRMS) in United States integrated delivery network healthcare claims and electronic health record (EHR) data
Le HV, Truong CT, Aaron Kamauu et al.
DOI: 10.1016/j.jval.2018.06.014Using Claims-Based Algorithms to Identify High Disease Activity for Relapsing Remitting Multiple Sclerosis Patients in US Healthcare Data
Le HV, Truong CT, Aaron W Kamauu et al.
Characteristics of Hospitalized Patients with Community-Acquired Bacterial Pneumonia (CABP) at Greatest Risk for Prolonged Hospital Length of Stay in an Integrated Delivery Network
Le HV, Kenneth LaPensee, Thomas Lodise, Canter Martin.
Patient Populations at Greatest Risk for Hospital Readmission or Repeat ED Visit within 30 Days of Hospital Discharge among Hospitalized Pts with Community-Acquired Pneumonia (CABP)
Kenneth LaPensee, Thomas Lodise, Canter Martin, Le HV.
Improving performance of algorithms to power unmet need and effectiveness in health economics and outcomes research using electronic health records and healthcare claims data sources
Le HV, Monica Kobayashi, Kamauu A, Schiffon L. Wong.
Identifying Relapsing-Remitting Multiple Sclerosis (RRMS) in United States Integrated Delivery Network Healthcare Claims Data
Le HV, Truong CT, Aaron W. C. Kamauu et al.
Identifying Relapsing-Remitting Multiple Sclerosis (RRMS) in United States Integrated Delivery Network Healthcare Electronic Health Record Data
Le HV, Monica G. Kobayashi, Aaron W. Kamauu et al.
Using algorithms to identify High Disease Activity Relapsing-Remitting Multiple Sclerosis patients using electronic health record data with natural language processing
Aaron W. Kamauu, Le HV, Truong CT, H.R. Crooke, J.R. Holmen, C.L. Fillmore, M. Sabidó-Espin, Schiffon L. Wong.
Using United States Integrated Delivery Network (IDN) Electronic Health Records (EHR)/Natural Language Processing (NLP)-Based Algorithms to Identify Relapses in Relapsing-Remitting Multiple Sclerosis (RRMS) Patients
Aaron W. Kamauu, Le HV, Truong CT, H.R. Crooke, J.R. Holmen, C.L. Fillmore, M. Sabidó-Espin, S.L. Wong.
Developing United States integrated delivery network (IDN) claims-based algorithms to identify relapses in relapsing-remitting multiple sclerosis (RRMS) patients
Aaron W. Kamauu, Le HV, Truong CT, H.R. Crooke, J.R. Holmen, C.L. Fillmore, M. Sabidó-Espin, Schiffon L. Wong.
Creating a healthcare claims-based adaptation of Kurtzke Functional Systems Scores for assessing multiple sclerosis severity and progression
Chi T.L. Truong, Le HV, Aaron W. Kamauu, J.R. Holmen, C.L. Fillmore, M.G. Kobayashi, M. Sabidó-Espin, Schiffon L. Wong.
Performance of Electronic Health Record- and Healthcare Claims-Based Algorithms to Identify Relapsing-Remitting Multiple Sclerosis in U.S. Integrated Delivery Network Healthcare Database
Aaron W. C. Kamauu, John R. Holmen, Christopher L. Fillmore, Le HV, Andy Wilson, Truong CT, Canter Martin, Schiffon L. Wong.
Potential cost saving opportunities with early use of omadacycline in hospitalized patients with ABSSSI with inadequate early response to vancomycin (VAN) plus piperacillin-tazobactam (TZP)
Kenneth La Pensee, Thomas Lodise, C. Graham et al, Le HV, Canter Martin, R. Mistry, K. Young.
Lessons learned in identifying relapsing-remitting multiple sclerosis (RRMS) in United States integrated delivery network healthcare claims and electronic health record (EHR) data
Le HV, Truong CT, Kamauu A, John Holmén, Chris Fillmore, Meritxell Sabidó-Espin, Schiffon Wong.
Characteristics of Hospitalized Patients with ABSSSI Treated with Vancomycin at Greatest Risk for Prolonged Hospital Length of Stay in an Integrated Delivery Network
Kenneth LaPensee, Thomas Lodise, Canter Martin, Le HV.
Patient Populations at Greatest Risk for Hospital Readmission or Repeat Emergency Department Visit within 30 Days of Hospital Discharge among Hospitalized Pts with Acute Bacterial Skin and Skin Structure Infections (ABSSSIs) Treated with Vancomycin
Kenneth LaPensee, Thomas Lodise, Canter Martin, Le HV.
Evaluation of Facebook and Twitter Monitoring to Detect Safety Signals for Medical Products: An Analysis of Recent FDA Safety Alerts
Carrie Elizabeth Pierce, Khaled Bouri, Carol Pamer et al.
DOI: 10.1007/s40264-016-0491-0Can Facebook and Twitter Monitoring Yield Earlier Detection of Safety Signals for Medical Products?
Carrie Elizabeth Pierce, Khaled Bouri, Carol Pamer, Scott Proestel, Harold Rodriguez, Le HV et al.
The Relationship Between Blood Eosinophils and Clinical Characteristics in a Cross-Sectional Study of a US Population-Based COPD Cohort
DiSantostefano RL, Le HV, Hinds D et al.
DOI: 10.1016/j.rmed.2016.01.013Can assessment of disease burden prior to changes in initial COPD maintenance treatment provide insight into remaining unmet needs? A retrospective database study in UK primary care
Sarah Landis, Keele Wurst, Le HV et al.
DOI: 10.1080/15412555.2016.1240159Identification of responders to inhaled corticosteroids in a COPD population using cluster analysis
David R. Hinds, DiSantostefano RL, Le HV et al.
DOI: 10.1136/bmjopen-2015010099Patient characteristics and treatment patterns over 24 months among COPD patients initiating long-acting bronchodilator prescription in the UK primary care setting
Yogesh S Punekar, Sarah Landis, Keele Wurst, Le HV.
DOI: 10.1186/s12931-015-0295-2Replicating FDA’s Sentinel Modular Programs
Le HV, Charlotte Carroll, John Logie, Carlyne Averell, Truong CT, Jennifer Christian.
Effects of Grouping of Medical Codes on the Performance of the High-Dimensional Propensity Score (hd-PS) Algorithm in Small Sample, Rare Outcome Incidence, and Low Exposure Prevalence
Le HV, Charles Poole, M. Alan Brookhart, Victor J. Schoenbach, Kathleen J. Beach, Til Stürmer.
Medications and Events Most Commonly Discussed in Facebook and Twitter
Heidi G. Bell, Lorrie Schifano, Laurie S. Anderson, Gregory E. Powell, Le HV, Harold Rodriguez.
The Relationship Between Blood Eosinophils and Clinical Characteristics in a Cross-Sectional Study of a US Population-Based COPD Cohort
DiSantostefano RL, Le HV, Hinds D, Bakerly ND.
COPD patient clusters that benefit most from fluticasone furoate added to vilanterol (FF/VI) vs. vilanterol (VI)
David Hinds, DiSantostefano RL, Le HV, Steven Pascoe.
Risk of pneumonia with inhaled corticosteroid versus long-acting bronchodilator regimens in chronic obstructive pulmonary disease: a new-user cohort study
DiSantostefano RL, Tim Sampson T, Le HV et al.
DOI: 10.1371/journal.pone.0097149Race-specific Prevalence and Risk Factors for Cutaneous Psoriasis in a U.S. Population-Based Cohort
Le HV, Truong CT, Julie Priest, Carlyne Averell, Charlotte Carroll, Martin Crane.
Identification of Heart Failure by Diagnoses and Cardiac Tests in a U.S. Electronic Health Records Database
Le HV, Truong CT, Julie Priest, Julia DiBello, Carlyne Averell.
Characteristics of patients newly prescribed a long-acting bronchodilator in the United Kingdom (UK)
Sarah Landis, Keele Wurst, Le HV, Hana Muellerova, Kourtney Davis.
Utilization of the Marketscan National Weights from the HIF to Estimate Quality Measures for Asthma, COPD, and Diabetes in the U.S. Commercial Employer Sponsored Health Insured Population
Charlotte Carroll, Le HV, Chao Lu, Julie Priest.
Economic cost of adverse events per course of therapy with commonly used regimens for the treatment of first-line chronic lymphocytic leukemia
Matthew Monberg, Amit Shukla, Le HV, Thomas Lin, Gaetano Bonifacio.
Examination Of Smoking Behavior And Comorbid Asthma In Adults With Severe COPD: Analysis Of The 2009-2010 National Health And Nutrition Examination Survey (NHANES)
Robert Y. Suruki, Le HV, Frank C. Albers.
DOI: 10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A5921Effects of Aggregation of Drug and Diagnostic Codes on the Performance of the High Dimensional Propensity Score Algorithm: An Empirical Example
Le HV, Charles Poole, Alan M. Brookhart et al.
DOI: 10.1186/1471-2288-13-142Benefits of different propensity score methods for evaluation of associations and channeling bias over time: Pneumonia and Inhaled corticosteroid in a COPD new user cohort
Le HV, Rachael L DiSantostefano, Tim Sampson, Truong CT, Kourtney J. Davis.
Prevalence, Selected Co-Morbidities and Systemic Therapies in a U.S. Population-Based Cutaneous Psoriasis Cohort
Le HV, Truong CT, Julie Priest, Carlyne Averell, Joe Eastman, Martin Crane.
Identification of Pregnancy by a Coding Algorithm in a U.S. Administrative Healthcare Database
Le HV, Truong CT, Charlotte Carroll, Julie Priest, Sara Ephross, Carlyne Averell.
A new-user cohort study comparing the risk of pneumonia in inhaled corticosteroids (ICS) and long-acting bronchodilators (LABD) in COPD
Rachael L DiSantostefano, T Sampson, Le HV, D Hinds, KJ Davis, N Diar Bakerly.
A Clinical Classification Dictionary for Read Codes in the General Practice Research Database
Le HV, Truong CT, David Webb, Lakshmi Mynepalli, Elizabeth Hodgson, Dimitri Bennett, John Logie, Carlyne Averell.
Development and Evaluation of Claims-Based Algorithms to Identify Advanced Chronic Kidney Disease
Le HV, Chi T.L. Truong, Charlotte F. Carroll, Jennifer B. Christian, David A. Webb, Samantha A. St. Laurent, Amit Shukla, John W. Logie, Carlyne Averell.
Performance of a semi-automated approach for risk estimation using a common data model for longitudinal healthcare databases
Le HV, Kathleen J Beach, Gregory Powell et al.
DOI: 10.1177/0962280211403599Propensity Score (PS) Variable Selection with the High Dimensional PS (hd−PS) Algorithm as a Function of Cohort Size, Exposure Prevalence, and Outcome Incidence
Le HV, Charles Poole, Alan Brookhart, Kathleen Beach, Til Stürmer.
Performance of a Coding Algorithm to Identify Drug-Induced Liver Injury (DILI) in a Longitudinal Healthcare Claims Database
Le HV, Truong CT, Carlyne Averell.
Incidence of Clinical Types and Risk Factors for Drug-Induced Liver Injury (DILI) in a Large Longitudinal Claims Database
Le HV, Truong CT, Carlyne Averell.
Using Observational Databases to Better Inform and Plan Clinical Trials: The Clinical Trial Planning Toolkit
Jennifer B. Christian, Samantha St. Laurent, Charlotte Carroll et al.
Clinical Patterns and Factors Associated with Drug-Induced Liver Injury (DILI) in a Large Longitudinal Healthcare Claims Database
Le HV, Truong CT, Carlyne Averell.
Effect of different trimming methods for propensity score distribution on risk estimates
Le HV, Kathleen Beach.
Association between cervical dysplasia and human papillomavirus in HIV seropositive women from Johannesburg South Africa
Cynthia Firnhaber, Le HV, Audrey Pettifor et al.
DOI: 10.1007/s10552-009-9475-zEffect of different trimming methods for propensity score distribution on risk estimates
Le HV, Kathleen Beach.
Automated robust mapping GPRD medical diagnosis Read codes to SNOMED CT for OMOP project
Le HV, Kathleen Beach.
Herpes simplex virus type 2 seropositivity among ever married women in north and south Vietnam: a population-based study
Le HV, Schoenbach VJ, Herrero R et al.
Advantages of Mapping ICD-9-CM into SNOMED CT Concepts and Hierarchy
Le HV, Kathleen Beach.
Performance of a Semi-automated Process for Estimation of Risk in a Claims Database
Kathleen Beach, Le HV, Powell G, Pattishall E, Ryan P, Mera R.
Advanced Topics in Causal Inference: Propensity Score and Related Models. Performance of a Semi-automated Process for Estimation of Risk in Observational Databases
Le HV et al.
A Systematic Approach for Unassigned ICD-9 Codes in a Health Insurance Claims Database
Le HV, Kathleen J Beach.
Effect of antiretroviral therapy on cervical lesions among HIV seropositive women in Johannesburg, South Africa
Firnhaber C, Le HV, Pettifor A, Schulze D, Williams S, Michelow P, Sanne I, Lewis D, William B, Williamson A, Allan B, Williams S, van der Horst C, Smith JS.
Thought Leadership
Blog posts and in-depth articles coming soon. Stay tuned for expert perspectives on RWE, AI in healthcare, and regulatory science.